Aging impairs myocardium-induced dilation in coronary arterioles: Role of hydrogen peroxide and angiotensin

▶Myocardium regulates coronary vascular tone by metabolites. ▶ Aging increases the production of superoxide in myocardium.▶ Aging decreases catalase and SOD activities in myocardium. ▶ Aging increases the production of H2O2 and angiotensin via the redox pathway. ▶ H2O2 and angiotensin regulate age-related decline of coronary vasodilation.