کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
191943 459731 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Electrochemical oxidation of acetaminophen in aqueous solutions: Kinetic evaluation of hydrolysis, hydroxylation and dimerization processes
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Electrochemical oxidation of acetaminophen in aqueous solutions: Kinetic evaluation of hydrolysis, hydroxylation and dimerization processes
چکیده انگلیسی

Electrochemical oxidation of acetaminophen (paracetamol) has been studied in various pHs using cyclic voltammetry and controlled-potential coulometry. The results indicate that electrochemically generated N-acetyl-p-benzoquinone-imine (NAPQI) participates in different type reactions based on solution's pH. It is hydrolyzed in strong acidic media and hydroxylated in strong alkaline media and also, it is dimerized in intermediate pHs. Furthermore, in this work, a simple method for electrochemical synthesis of acetaminophen's dimer is described. In addition, in various pHs, based on related mechanism, the observed homogeneous rate constants (kobs) of hydrolysis, hydroxylation and dimerization reactions were estimated by comparing the experimental cyclic voltammetric responses with the digital-simulated results. The most amounts of kobs are calculated in pHs less than 2 and more than 9. In this study, the least observed homogeneous rate constant (kobs) belongs to pHs 5.0 and 9.0.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Electrochimica Acta - Volume 54, Issue 28, 1 December 2009, Pages 7407–7415
نویسندگان
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