کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1919910 1535678 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polymorphisms of pro-inflammatory genes and Alzheimer's disease risk: A pharmacogenomic approach
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Polymorphisms of pro-inflammatory genes and Alzheimer's disease risk: A pharmacogenomic approach
چکیده انگلیسی

Clinically and pathologically Alzheimer's disease (AD) represents a sequential progressive neurodegenerative disorder. AD is etiologically heterogeneous and accounts for a majority of dementia in western societies. Inflammation clearly occurs in pathologically vulnerable regions of the AD brain and the search for genetic factors influencing the pathogenesis of AD has lead to the identification of numerous gene polymorphisms that might act as susceptibility modifiers. Accordingly, several reports have indicated that the risk of AD is substantially influenced by several genetic polymorphisms in the promoter region, or other untranslated regions, of genes encoding inflammatory mediators, although not all the studies were replied. Here, we review several data suggesting that inflammatory genetic variation may contribute to AD susceptibility. All together this information may represent the basis both for future recognition of individuals at risk and for the pharmacogenomic driving of drug responsiveness.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 128, Issue 1, January 2007, Pages 67–75
نویسندگان
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