کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1920027 1535690 2006 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Candidate genes for late-onset Alzheimer's disease: Focus on chromosome 12
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Candidate genes for late-onset Alzheimer's disease: Focus on chromosome 12
چکیده انگلیسی

In recent years, there was an increasing interest on candidate genes may play an important role in the development of Alzheimer's disease (AD). Several genome wide screens have undertaken so far or expanded recently, and suggested a number of genomic areas that may contain novel susceptibility genes for AD, in particular most compelling have been the findings on chromosome 12. Polymorphisms in different susceptibility genes on chromosome 12 (A2M, LRP1, CP2 and OLR1) are now being suggested as possible genetic markers for increased risk of developing AD. However, many of these studies are controversial and have shown conflicting results. Thus far, the search for the chromosome 12 Alzheimer's gene must continue and there are several other genes in this region that we are looking at. In this article, we focused on the current knowledge of the genetics of familial late-onset and sporadic AD linked to the chromosome 12, and the future search for other candidate genes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 127, Issue 1, January 2006, Pages 36–47
نویسندگان
, , , , , , , ,