کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1924511 1535876 2014 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles
ترجمه فارسی عنوان
عامل انقباض یوکاریوتی 2 کیناز، یک آنزیم غیر معمول با چندین نقش
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

Eukaryotic elongation factor 2 kinase (eEF2K) is a member of the small group of atypical ‘α-kinases’. It phosphorylates and inhibits eukaryotic elongation factor 2, to slow down the elongation stage of protein synthesis, which normally consumes a great deal of energy and amino acids. The activity of eEF2K is normally dependent on calcium ions and calmodulin. eEF2K is also regulated by a plethora of other inputs, including inhibition by signalling downstream of anabolic signalling pathways such as the mammalian target of rapamycin complex 1. Recent data show that eEF2K helps to protect cancer cells against nutrient starvation and is also cytoprotective in other settings, including hypoxia. Growing evidence points to roles for eEF2K in neurological processes such as learning and memory and perhaps in depression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advances in Biological Regulation - Volume 55, May 2014, Pages 15–27
نویسندگان
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