کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1924930 | 1536326 | 2015 | 12 صفحه PDF | دانلود رایگان |
• Various techniques used to study the drug–DNA interactions are reviewed.
• The results obtained using these techniques are simple and easy to interpret.
• Figures clearly demarcate intercalative and non-intercalative binding mode.
Drug–DNA interactions have been extensively studied in the recent past. Various techniques have been employed to decipher these interactions. DNA is a major target for a wide range of drugs that may specifically or non-specifically interact with DNA and affect its functions. Interaction between small molecules and DNA are of two types, covalent interactions and non-covalent interactions. Three major modes of non-covalent interactions are electrostatic interactions, groove binding and intercalative binding. This review primarily focuses on discussing various techniques used to study non-covalent interactions that occur between drugs and DNA. Additionally, we report several techniques that may be employed to analyse the binding mode of a drug with DNA. These techniques provide data that are reliable and simple to interpret.
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Journal: Archives of Biochemistry and Biophysics - Volume 576, 15 June 2015, Pages 49–60