کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1924979 1536320 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis
ترجمه فارسی عنوان
کوئرستین التهاب را کاهش داده و دفاع آنتی اکسیدانی را در آرتریت کمکی موش بالتیک کاهش می دهد
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Administration of quercetin is investigated in a rat model of adjuvant arthritis.
• Quercetin ameliorates several markers of inflammation and oxidative stress.
• Quercetin inhibits inflammation mainly by suppressing NF-κB and ERK pathways.

Novel therapies for rheumatoid arthritis also include the use of naturally occurring compounds possessing antioxidant properties. In the present work, the effects of oral administration of quercetin were investigated in a rat model of adjuvant arthritis. Arthritis was induced by a single intradermal injection of heat-inactivated Mycobacterium butyricum in incomplete Freund's adjuvant. The experimental groups were treated with an oral daily dose of 150 mg/kg b.w. of quercetin for 28 days. Results indicated that quercetin was able to ameliorate all markers of inflammation and oxidative stress measured. Quercetin lowered levels of interleukin-1β, C-reactive protein, and monocyte chemotactic protein-1 and restored plasma antioxidant capacity. In addition, quercetin inhibited the enzymatic activity of pro-inflammatory 12/15-lipoxygenase in lung and liver and increased the expression of heme oxygenase-1 in joint and lung of arthritic rats. Finally, quercetin inhibited the 2-fold increase of NF-қB activity observed in lung, liver and joint after induction of arthritis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 583, 1 October 2015, Pages 150–157
نویسندگان
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