کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1925344 | 1536366 | 2013 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Alterations of corticostriatal plasticity by ammonium and rescue by green tea polyphenols Alterations of corticostriatal plasticity by ammonium and rescue by green tea polyphenols](/preview/png/1925344.png)
Hyperammonemia is a major pathophysiological factor in encephalopathies associated with acute and chronic liver failure. On mouse brain slice preparations we analyzed the effects of ammonium on the characteristics of corticostriatal long-term potentiation (LTP) induced by high-frequency electrical stimulation (HFS) of cortical input and the long-lasting effects of pharmacological NMDA receptor (NMDAR) activation. Ammonium chloride exposure enhanced the expression of HFS-induced LTP at the expense of LTD and promoted the generation of NMDA-induced LTD. This treatment did not affect two NMDAR-independent forms of plasticity: taurine-induced LTP and histamine-induced LTD. Alterations in NMDA-induced plasticity were prevented by treatment with green tea polyphenols suggesting the contribution of oxidative stress to the expression of abnormal corticostriatal plasticity.
► Synaptic plasticity in corticostriatal pathway is sensitive to hyperammonemia.
► Alterations induced by ammonia are attributable to the enhanced function of NMDA glutamate receptors.
► Polyphenolic antioxidants from green tea prevent ammonia-induced alterations in NMDA-induced plasticity.
Journal: Archives of Biochemistry and Biophysics - Volume 536, Issue 2, 15 August 2013, Pages 176–182