کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1925729 | 1536411 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of ciliary motility: Conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9 + 2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.
► Review of regulation of ciliary and flagellar motility by phosphorylation.
► Kinases and phosphatases anchored in the ciliary axoneme.
► Proteomic studies identifying ciliary proteins and phosphoprotein substrates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 510, Issue 2, 15 June 2011, Pages 93–100
Journal: Archives of Biochemistry and Biophysics - Volume 510, Issue 2, 15 June 2011, Pages 93–100
نویسندگان
Maureen Wirschell, Ryosuke Yamamoto, Lea Alford, Avanti Gokhale, Anne Gaillard, Winfield S. Sale,