The aryl hydrocarbon receptor nuclear translocator-interacting protein 2 suppresses the estrogen receptor signaling via an Arnt-dependent mechanism

► ER signaling can be modulated by an Arnt-dependent mechanism. ► An Arnt-interacting protein Ainp2 suppresses E2-induced, Arnt-dependent luciferase expression. ► Ainp2 suppresses the E2-induced, Arnt-dependent upregulation of the GREB1 message. ► Ainp2 inhibits the E2-driven recruitment of Arnt to the GREB1 promoter.