کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1927114 | 1536499 | 2007 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1) Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1)](/preview/png/1927114.png)
The regulation of divalent zinc has been observed in a wide range of organisms. Since this metal is an essential nutrient, but also toxic in excess, zinc homeostasis is crucial for normal cellular functioning. The metal-responsive-element-binding transcription factor-1 (MTF-1) is a key regulator of zinc in higher eukaryotes ranging from insects to mammals. MTF-1 controls the expression of metallothioneins (MTs) and a number of other genes directly involved in the intracellular sequestration and transport of zinc. Although the diverse functions of MTF-1 extend well beyond zinc homeostasis to include stress-responses to heavy metal toxicity, oxidative stress, and selected chemical agents, in this review we focus on the recent advances in understanding the mechanisms whereby MTF-1 regulates MT gene expression to protect the cell from fluctuations in environmental zinc. Particular emphasis is devoted to recent studies involving the Cys2His2 zinc finger DNA-binding domain of MTF-1, which is an important contributor to the zinc-sensing and metal-dependent transcriptional activation functions of this protein.
Journal: Archives of Biochemistry and Biophysics - Volume 463, Issue 2, 15 July 2007, Pages 201–210