کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1927519 | 1536529 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Possible involvement of NO-mediated oxidative stress in induction of rat forestomach damage and cell proliferation by combined treatment with catechol and sodium nitrite
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Forestomach8-hydroxydeoxyguanosine - 8 هیدروکسی دیواکسی گوآزینOxidative stress - تنش اکسیداتیوHydroxyl radical - رادیکال هیدروکسیلElectron spin resonance - رزونانس اسپین الکترونCarcinogenesis - سرطانزاییnitrotyrosine - نیتروتیروستینSodium nitrite - نیتریت سدیمNitric oxide - نیتریک اکسیدPeroxynitrite - پروکسی نیتریتCatechol - کاتچول
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To clarify the mechanisms underlying forestomach carcinogenesis in rats by co-treatment with catechol and sodium nitrite (NaNO2), we investigated the involvement of oxidative stress resulting from reaction of the two compounds. Since generation of semiquinone radical, hydroxyl radical (OH), and peroxynitrite (ONOOâ) arose through the reaction of catechol with NO, we proposed that superoxide resulting from catechol oxidation reacted with excess NO, consequently yielding OH via ONOOâ. Male F344 rats were co-treated with 0.2% catechol in the diet and 0.8% NaNO2 in the drinking water for 2 weeks. Prior to occurrence of histological evidence indicating epithelial injury and hyperplasia, 8-hydroxydeoxyguanosine levels in forestomach epithelium significantly increased from 12Â h together with appearance of immunohistochemically nitrotyrosine-positive epithelial cells. There were no remarkable changes in rats given each chemical alone. We conclude that oxidative stress due to NO plays an important role in induction of forestomach epithelial damage, cell proliferation, and thus presumably forestomach carcinogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 447, Issue 2, 15 March 2006, Pages 127-135
Journal: Archives of Biochemistry and Biophysics - Volume 447, Issue 2, 15 March 2006, Pages 127-135
نویسندگان
Yuji Ishii, Takashi Umemura, Keita Kanki, Yuichi Kuroiwa, Akiyoshi Nishikawa, Rie Ito, Koichi Saito, Hiroyuki Nakazawa, Masao Hirose,