کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1927892 1050268 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-obesity potential of enzymatic fragments of hyaluronan on high-fat diet-induced obesity in C57BL/6 mice
ترجمه فارسی عنوان
پتانسیل ضد چاقی از قطعات آنزیمی هیالورونان بر چاقی ناشی از رژیم غذایی با چربی در موش ماده C57BL / 6
کلمات کلیدی
انعطاف پذیری؛ قطعات هیالورونان؛ رژیم غذایی با چربی بالا؛ PPAR-Alpha؛ استئاتوز کبدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Fifty kDa of hyaluronan fragment reduced body weight in high-fat mice.
• Hyaluronan fragment ameliorates hyperlipidemia and hyperleptinemia.
• Hyaluronan fragment decreased liver steatosis.
• Hyaluronan fragment reduced hepatic expression of PPAR-alpha and its target genes.

Hyaluronan has diverse biological activities depending on its molecular size. The hyaluronan fragments (50 kDa) can decrease adipogenic differentiation in vitro. However, in vivo anti-obesitic effects of hyaluronan fragments have not been elucidated. Therefore, we examined the anti-obesity effects of hyaluronan fragments on high-fat diet induced obesity in C57BL/6 mice. Oral administration of hyaluronan fragments (200 mg/kg for 8 weeks) decreased body weight, adipose tissues, serum lipid (low-density lipoprotein cholesterol, triglyceride), and leptin level. Hyaluronan fragments decreased the hypertrophy of adipose tissue and ameliorated liver steatosis. The mRNA expression of leptin was reduced in adipocyte by treatment with hyaluronan fragments. Additionally, hyaluronan fragments enhanced the mRNA expression of PPAR-α and its target genes UCP-2 and decreased mRNA expression of PPAR- γ and fatty acid synthase in liver. In conclusions, hyaluronan fragments had marked effects on inhibiting the development of obesity in obese mice fed the high-fat diet. It suggested that enhancing PPAR-α and suppressing PPAR-γ expression are two possible mechanisms for the anti-obesitic effect of hyaluronan fragments.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 473, Issue 1, 22 April 2016, Pages 290–295
نویسندگان
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