کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1928352 1536774 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High fat diet promotes achievement of peak bone mass in young rats
ترجمه فارسی عنوان
رژیم غذایی با چربی بالا باعث رسیدن به حداکثر توده استخوان در موش های جوان می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• High fat diet helps in achieving peak bone mass at younger age.
• Shifting from high fat to normal diet normalizes obese parameters.
• Bone parameters are sustained even after withdrawal of high fat diet.

The relationship between obesity and bone is complex. Epidemiological studies demonstrate positive as well as negative correlation between obesity and bone health. In the present study, we investigated the impact of high fat diet-induced obesity on peak bone mass. After 9 months of feeding young rats with high fat diet, we observed obesity phenotype in rats with increased body weight, fat mass, serum triglycerides and cholesterol. There were significant increases in serum total alkaline phosphatase, bone mineral density and bone mineral content. By micro-computed tomography (μ-CT), we observed a trend of better trabecular bones with respect to their microarchitecture and geometry. This indicated that high fat diet helps in achieving peak bone mass and microstructure at younger age. We subsequently shifted rats from high fat diet to normal diet for 6 months and evaluated bone/obesity parameters. It was observed that after shifting rats from high fat diet to normal diet, fat mass, serum triglycerides and cholesterol were significantly decreased. Interestingly, the gain in bone mineral density, bone mineral content and trabecular bone parameters by HFD was retained even after body weight and obesity were normalized. These results suggest that fat rich diet during growth could accelerate achievement of peak bone mass that is sustainable even after withdrawal of high fat diet.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 455, Issues 1–2, 5 December 2014, Pages 133–138
نویسندگان
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