کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1928417 | 1050355 | 2014 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: CD160 expression defines a uniquely exhausted subset of T lymphocytes in HTLV-1 infection CD160 expression defines a uniquely exhausted subset of T lymphocytes in HTLV-1 infection](/preview/png/1928417.png)
• CD160/HVEM pathway involved in modulation of T-cell response to HTLV-1 infection.
• We report an inhibitory role for CD160 on HTLV-1 specific CD8+ T cells.
• CD160 pathway blockade using anti-CD160 or HVEM antibodies improves T cell function.
• Higher CD160: BTLA proportion on total CD8+ T and HTLV-1 specific CD8+ T cells.
• Increased expression of 2B4 and PD1 on the CD160+CD8+ subset.
HTLV-1 infection is a life-long retroviral infection. Chronic viral antigenic stimulation induces persistent infection which results in a clinically asymptomatic carrier state. Only a minor proportion of infected individuals develop adult T cell leukemia/lymphoma (ATLL) or HTLV-1-associated myelopathy/tropical spastic myelopathy (HAM/TSP). This is dependent on a balance of host and genetic factors. CD8+ cytotoxic T lymphocyte function is important in the immune response against viral infection; however, the contribution of CD160 receptor associated with CD8+ T lymphocytes is unclear. Thus, we sought to decipher its role on CTL function in HTLV-1 infection. Here, we report high frequencies of CD160 on CD8+ T cells, with significantly higher levels on HTLV-1 specific CD8+ T cells. Intercepting the CD160 pathway via blockade of the receptor or its ligand, herpes virus entry mediator (HVEM) resulted in improved perforin production and CD107a degranulation of HTLV-1 specific CD8+ T cells. Analysis of the CD160-expressing CD8+ cells demonstrated a unique subset associated with a highly differentiated effector memory based on CD45RA and CCR7 co-expression, increased expression of inhibitory molecules, 2B4 and PD1. Altogether, these results suggest a role for CD160/HVEM pathway in regulating immune response against HTLV-1 infection which may prove promising in the development of immune therapies for the treatment of HTLV-1 infection and other associated disorders.
Journal: Biochemical and Biophysical Research Communications - Volume 453, Issue 3, 24 October 2014, Pages 379–384