کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1928687 1050411 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Downregulation of BTG3 in non-small cell lung cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Downregulation of BTG3 in non-small cell lung cancer
چکیده انگلیسی


• BTG3 expression is frequently suppressed in NSCLC.
• Two BTG3 isoforms present in lung cancer.
• BTG3 inhibits lung cancer growth.
• Restoration of BTG3 inhibits autophagy in lung cancer cells.

BTG3 is identified as a tumor suppressor gene in some malignancies. Btg3-deficient mice display a higher incidence of lung cancer. These results suggest that BTG3 plays an important role in lung tumorigenesis, although the underlying mechanisms are unknown. The BTG3 expression was detected using immunohistochemical staining and our results showed that the expression of BTG3 was reduced in lung cancer compared to benign lung tissues. We identified two BTG3 isoforms present in lung cancer: Full-length BTG3 and BTG3b lacking the 44 amino acids. BTG3 was predominantly expressed in benign lung tissues, whereas its expression was generally undetectable in lung cancer and cancer cell lines. Functional analysis revealed that BTG3 but not BTG3b inhibited lung cancer growth. Our results disclosed an important role of BTG3 in lung tumorigenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 437, Issue 1, 19 July 2013, Pages 173–178
نویسندگان
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