کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1928719 1050418 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association between MIF gene polymorphisms and carotid artery atherosclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Association between MIF gene polymorphisms and carotid artery atherosclerosis
چکیده انگلیسی


• Atherosclerosis is a chronic inflammatory disorder.
• MIF plays an important role in the regulation of immune responses.
• The relationship between the MIF gene polymorphisms and carotid artery atherosclerosis (CAA) were investigated.
• Polymorphisms in the MIF gene promoter were associated with severity of CAA.
• MIF gene variants may serve as markers for individual susceptibility to CAA.

Atherosclerosis is a chronic inflammatory disorder. Macrophage migration inhibitory factor (MIF) is a potent cytokine that plays an important role in the regulation of immune responses. Polymorphisms including five- to eight-repeat CATT variants ((CATT)5–8) and G-173C in the promoter region of the MIF gene are associated with altered levels of MIF gene transcription. The purpose of the study is to investigate the relationship between promoter polymorphisms of the MIF gene and the severity of carotid artery atherosclerosis (CAA). The severity of CAA was assessed in 593 individuals with a history of ischemic stroke by using sonographic examination, and the MIF promoter polymorphisms of these individuals were genotyped. The carriage of (CATT)7 (compared to genotypes composed of (CATT)5, (CATT)6, or both), carriage of C allele (compared to GG), and carriage of the haplotype (CATT)7-C (compared to genotypes composed of (CATT)5-G, (CATT)6-G, or both) were significantly associated with an increase in the severity of CAA. We conclude that polymorphisms in the MIF gene promoter are associated with CAA severity in ischemic stroke patients. These genetic variants may serve as markers for individual susceptibility to CAA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 435, Issue 2, 31 May 2013, Pages 319–322
نویسندگان
, , , , , , ,