کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1928817 | 1050427 | 2013 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors](/preview/png/1928817.png)
Insulin-like peptide 5 (INSL5) is a member of the insulin superfamily, and is a potent agonist for RXFP4. We have shown that INSL5 is expressed in enteroendocrine cells (EECs) along the colorectum with a gradient increase toward the rectum. RXFP4 is ubiquitously expressed along the digestive tract. INSL5-positive EECs have little immunoreactivity to chromogranin A (CgA) and might be a unique marker of colorectal EECs. CgA-positive EECs were distributed normally along the colorectum in INSL5 null mice, suggesting that INSL5 is not required for the development of CgA-positive EECs. Exogenous INSL5 did not affect the proliferation of human colon cancer cell lines, and chemically-induced colitis in INSL5 null mice did not show any significant changes in inflammation or mucosal healing compared to wild-type mice. In contrast, all of the rectal neuroendocrine tumors examined co-expressed INSL5 and RXFP4. INSL5 may be a unique marker of colorectal EECs, and INSL5–RXFP4 signaling might play a role in an autocrine/paracrine fashion in the colorectal epithelium and rectal neuroendocrine tumors.
► INSL5 is expressed in enteroendocrine cells along the colorectum.
► INSL5 is expressed increasingly from proximal colon to rectum.
► INSL5 co-localizes rarely with chromogranin A.
► All rectal neuroendocrine tumors examined expressed INSL5.
Journal: Biochemical and Biophysical Research Communications - Volume 432, Issue 4, 22 March 2013, Pages 586–592