کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1928880 1050430 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Emerging roles of Lipasin as a critical lipid regulator
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Emerging roles of Lipasin as a critical lipid regulator
چکیده انگلیسی

Patients with metabolic syndrome are at high risk for developing atherosclerotic cardiovascular diseases and diabetes. In addition to total cholesterol, LDL-C and HDL-C, elevated plasma triglycerides (TG) are increasingly recognized as an independent risk factor for cardiovascular diseases. Recently 3 groups independently reported the identification and characterization of a novel blood lipid regulator, Lipasin/RIFL/ANGPTL8, which here is referred to as Lipasin for its lipoprotein lipase inhibition effect and for being a circulating factor denoted by ‘in’. Being highly enriched in the liver, Lipasin is a hepatocyte-derived circulating factor that regulates plasma TG levels. Lipasin is nutritionally regulated, as its mRNA levels in liver and fat as well as its protein level in serum are reduced by fasting. Mice deficient for Lipasin have lower serum TG levels; conversely, its adenovirus-mediated overexpression increases serum TG levels, in part, through promoting ANGPTL3 cleavage, releasing its N-terminal domain that inhibits lipoprotein lipase. Lipasin sequence variations are associated with LDL-C and HDL-C concentrations in humans. Being lipogenic, Lipasin is highly induced during adipogenesis. Levels of Lipasin and ANGPTL4 show opposite changes in response to fasting or cold environment. Lipasin, a novel but atypical ANGPTL family member, is emerging as a critical lipid regulator and a potential drug target.


► Lipasin is a novel but atypical ANGPTL family member.
► Lipasin is enriched in liver and nutritionally regulated.
► Lipasin is a hepatocyte-secreted circulating factor.
► Lipasin deficient (overexpression) mice exhibit reduced (increased) serum triglycerides.
► Lipasin promotes ANGPTL3 cleavage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 432, Issue 3, 15 March 2013, Pages 401–405
نویسندگان
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