کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1929134 | 1050446 | 2012 | 6 صفحه PDF | دانلود رایگان |
α-Iso-cubebenol, a natural compound isolated from the Schisandra chinensis fruit, strongly enhances survival rate in cecal ligation and puncture (CLP) challenge-induced sepsis. Mechanistically, α-iso-cubebenol markedly reduces viable bacteria in the peritoneal fluid and peripheral blood, by increasing production of superoxide anion. α-Iso-cubebenol also significantly attenuates widespread immune cell apoptosis in a mouse CLP sepsis model, and inhibits the production of proinflammatory cytokines including interleukin-1β (IL-1β) and IL-6 in CLP mice and lipopolysaccharide-stimulated splenocytes. Taken together, the results indicate that α-iso-cubebenol can reverse the progression of septic shock by triggering multiple protective downstream signaling pathways to enhance microbial killing and maintain organ function and leukocyte survival.
► α-Iso-cubebenol showed therapeutic effect against experimental sepsis.
► α-Iso-cubebenol enhanced the bactericidal effects of phagocytic cells.
► α-Iso-cubebenol reduced immune cell apoptosis.
► α-Iso-cubebenol significantly reduced the production of IL-1β in sepsis model.
► The finding suggests a novel therapeutic approach to treat polymicrobial sepsis.
Journal: Biochemical and Biophysical Research Communications - Volume 427, Issue 3, 26 October 2012, Pages 547–552