Sperm-specific glyceraldehyde-3-phosphate dehydrogenase is expressed in melanoma cells

► Melanoma cells were assayed for expression of sperm-specific glycolytic enzyme GAPDS. ► GAPDS fragment lacking N-terminal amino acid sequence is revealed in melanoma cells. ► The revealed GAPDS species form hybrid tetramers with somatic isoenzyme GAPD. ► Immunochemical staining of melanoma cells revealed native GAPDS in the cytoplasm.