کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1929234 | 1050449 | 2012 | 4 صفحه PDF | دانلود رایگان |
Evidence suggests that ß-Adrenergic receptor signaling increases heart rate and force through not just cyclic AMP but also the Ca2+-releasing second messengers NAADP (nicotinic acid adenine dinucleotide phosphate) and cADPR (cyclic ADP-ribose). Nevertheless, proof of the physiological relevance of these messengers requires direct measurements of their levels in response to receptor stimulation. Here we report that in intact Langendorff-perfused hearts ß-adrenergic stimulation increased both messengers, with NAADP being transient and cADPR being sustained. Both NAADP and cADPR have physiological and therefore pathological relevance by providing alternative drug targets in the ß-adrenergic receptor signaling pathway.
► We measured cADPR and NAADP in hearts during ß-adrenergic stimulation.
► ß-adrenergic stimulation increased both cADPR and NAADP.
► The increase in NAADP was transient whereas the increase in cADPR was sustained.
Journal: Biochemical and Biophysical Research Communications - Volume 427, Issue 2, 19 October 2012, Pages 326–329