کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1929331 | 1050452 | 2012 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Toll-like receptor (TLR) 3 as a surrogate sensor of retroviral infection in human cells Toll-like receptor (TLR) 3 as a surrogate sensor of retroviral infection in human cells](/preview/png/1929331.png)
The toll-like receptor (TLR)-7 has been shown to sense the retroviral infection. However, a surrogate sensor has been implicated. We examined whether retrovirus serves as a TLR3 ligand in human cells by utilizing cell lines LNCaP and PC-3 lacking TLR7, and the xenotropic murine leukemia virus-relamoted virus (XMRV) insensitive to human tripartite motif-containing (TRIM) 5, a newly characterized pattern recognition receptor (PRR). A dominant-negative TLR3 or a chemical inhibitor of TLR3 attenuated the XMRV-induced IP-10/CXCL10 expression, a marker of TLR3 response. These data clearly indicated that retroviral infection exemplified by XMRV activates the TLR3 signal in human cells.
► TLR3 was shown to serve as a surrogate sensor of retrovirus in human cells.
► TLR3’s anti-retroviral functions were assessed in a system unaffected TRIM5.
► TLR3’s recognition of XMRV was investigated by genetic and chemical approaches.
Journal: Biochemical and Biophysical Research Communications - Volume 424, Issue 3, 3 August 2012, Pages 519–523