کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1929466 | 1050460 | 2012 | 4 صفحه PDF | دانلود رایگان |

Mutations in ALS2 gene/alsin are associated with recessive forms of motor neuron disorders including Juvenile Amyotrophic Lateral Sclerosis (JALS), Infantile-onset Ascending Hereditary Spastic Paraplegia (IAHSP) and Juvenile Primary Lateral Sclerosis (JPLS). In this study, we show that alsin and another MND-linked protein, spartin are related to each other both at mRNA and protein levels in Neuro2a cells. We observed significant alterations in spartin expression in alsin knock-down conditions. We further found that both proteins colocalize in N2a cells and spartin isoform-a precipitates with alsin in the same protein complex. In the light of these results we suggest that alsin and spartin may interact each other physically.
► In alsin KD cells, Spg20 mRNA levels are significantly altered.
► Alsin and spartin proteins colocalize and coprecipitate in N2a cells.
► Alsin and spartin may physically interact, having related functions in EGFR trafficking.
Journal: Biochemical and Biophysical Research Communications - Volume 427, Issue 1, 12 October 2012, Pages 1–4