Analysis of the CD23-αv integrin interaction: A study with model peptides

► αvβ3 and αvβ5 integrins bind the human CD23 protein via an RKC motif. ► The interaction of αv integrins and CD23 is cation-independent. ► Single substitutions in RKC do not abolish integrin binding or biological function. ► Integrin binding of RKC and RGD motifs have distinctive characteristics.