Negative regulation of Odd-skipped related 2 by TGF-beta achieves the induction of cellular migration and the arrest of cell cycle

► TGF-β down-regulated Osr2 expression via Smad3/Smad4 and p38/ATF2 signaling molecules. ► Osr2 promoter possessed Smad3/4 and ATF2 binding elements. ► Osr2 reduced the level of cellular migration and stimulated cell-cycle progression.