Crystal structure and thermostability of a putative α-glucosidase from Thermotoga neapolitana

► We determined crystal structure of a putative α-glucosidase from Thermotoga neapolitana. ► We examine the dimeric assembly and Mn2+ coordination in the structure. ► We examine that numerous arginine-mediated salt bridges in the structure. ► We confirm that the salt bridges play an important role in the thermostability of the enzyme.