Crystal structure of the mismatch-specific thymine glycosylase domain of human methyl-CpG-binding protein MBD4

► This is the first structural information of human MBD4 glycosylase domain. ► The helices, including α9, α8, α1, and 12-residue preceding α1, form a hydrophobic core of the protein. ► The different of charge distributions on the surface of the protein between the human and mouse MBD4.