کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1930391 | 1050507 | 2011 | 6 صفحه PDF | دانلود رایگان |
Rikkunshito (RKT), a Japanese traditional medicine, has been shown to stimulate food intake in rats with cisplatin-induced anorexia; however, the underlying mechanisms remain unknown. In this study, we investigated whether RKT is involved in the degradation of peripheral ghrelin. RKT inhibited decreases in plasma ghrelin level and enhanced acyl- to desacyl-ghrelin (A/D) ratio in cisplatin-treated rats. Several components of RKT demonstrated inhibitory activity against ghrelin deacylating enzymes. In addition, 10-gingerol, a component of RKT, inhibited exogenous ghrelin deacylation. Therefore, RKT may enhance plasma acyl-ghrelin level, at least in part, by inhibiting the circulating ghrelin degrading enzyme.
► Rikkunshito (RKT) has been shown to stimulate ghrelin level in cisplatin-treated rats.
► We hypothesised that an increase in ghrelin level would inhibit the ghrelin degradation process.
► We investigated the effects of RKT on ghrelin deacylation in normal and cisplatin-treated rats.
► RKT and its component 10-gingerol inhibit the degradation of acyl-ghrelin by carboxylesterase inhibition.
► Carboxylesterase inhibition improved cisplatin-induced anorexia.
Journal: Biochemical and Biophysical Research Communications - Volume 412, Issue 3, 2 September 2011, Pages 506–511