کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1930425 1050510 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mycobacterium tuberculosislpdC, Rv0462, induces dendritic cell maturation and Th1 polarization
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Mycobacterium tuberculosislpdC, Rv0462, induces dendritic cell maturation and Th1 polarization
چکیده انگلیسی

Mycobacterium tuberculosis, the etiological factor of pulmonary tuberculosis, causes significant morbidity and mortality worldwide. Activation of host immune responses for containment of mycobacterial infections involves participation of innate immune cells, such as dendritic cells (DCs). In this study, we demonstrated that the gene encoding lipoamide dehydrogenase C (lpdC) from M. tuberculosis, Rv0462, induce maturation and activation of DCs involved in the MAPKs signaling pathway. Moreover, Rv0462-treated DCs activated naïve T cells, polarized CD4+ and CD8+ T cells to secrete IFN-γ in syngeneic mixed lymphocyte reactions, which would be expected to contribute to Th1 polarization of the immune response. Our results suggest that Rv0462 can contribute to the innate and adaptive immune responses during tuberculosis infection, and thus modulate the clinical course of tuberculosis.


► Treatment with Rv0462 induces the expression of surface molecules and the production of cytokines in DCs.
► Rv0462 induces the activation of MAPKs.
► Rv0462-treated DCs enhances the proliferation of CD4+ T cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 411, Issue 3, 5 August 2011, Pages 642–647
نویسندگان
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