کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1930581 1050518 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The sequence d(CGGCGGCCGC) self-assembles into a two dimensional rhombic DNA lattice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The sequence d(CGGCGGCCGC) self-assembles into a two dimensional rhombic DNA lattice
چکیده انگلیسی

We report here the crystal structure of the partially self-complementary decameric sequence d(CGGCGGCCGC), which self assembles to form a four-way junction with sticky ends. Each junction binds to four others through Watson–Crick base pairing at the sticky ends to form a rhombic structure. The rhombuses bind to each other and form two dimensional tiles. The tiles stack to form the crystal. The crystal diffracted in the space group P1 to a resolution of 2.5 Å. The junction has the anti-parallel stacked-X conformation like other junction structures, though the formation of the rhombic net noticeably alters the details of the junction geometry.


► This is the first crystal structure of a four-way junction with sticky ends.
► Four junction structures bind to each other and form a rhombic cavity.
► Each rhombus binds to others to form ‘infinite’ 2D tiles.
► This is an example of bottom-up fabrication of a DNA nano-lattice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 407, Issue 3, 15 April 2011, Pages 548–551
نویسندگان
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