STRAP regulates c-Jun ubiquitin-mediated proteolysis and cellular proliferation

► STRAP is specifically correlated with c-Jun expression and activation in fibroblasts. ► STRAP inhibits c-Jun ubiquitylation in vivo and prolongs the half-life of c-Jun. ► STRAP expression increases expression of the AP-1 target gene, cyclin D1, and promotes cell autonomous growth.