Inhibition of HIV-1 infection of peripheral blood mononuclear cells by a monoclonal antibody that binds to phosphoinositides and induces secretion of β-chemokines

► A murine mAb to phosphoinositides neutralizes HIV-1 infection of cells in vitro. ► Neutralization occurred because of secretion of β-chemokines inhibitory to HIV-1. ► Secretion of β-chemokines was induced by the mAb even in the absence of HIV-1. ► Phosphoinositides are intracellular, thus the mAb may have exerted intracellular effects. ► A novel intracellular stimulation by a mAb of HIV-inhibitory chemokines is proposed.