Increased transient receptor potential vanilloid type 1 (TRPV1) channel expression in hypertrophic heart

► Transient receptor potential vanilloid type 1 (TRPV1) channels may cause heart hypertrophy. ► TRPV1 transcripts were increased in transgenic mice overexpressing the catalytic subunit alpha of protein phosphatase 2A alpha (PP2Ac alpha). ► Discoidin domain receptor family, member 2 was significantly higher in PP2Ac compared to wild-type mice and TRPV1 knockout mice. ► The expression of miR21 was significantly higher in PP2Ac alpha compared with TRPV1 knockout mice. ► The study suggests an important role of TRPV1 in the pathogenesis of genetically associated heart hypertrophy.