Distribution of radiolabeled l-glutamate and d-aspartate from blood into peripheral tissues in naive rats: Significance for brain neuroprotection

► Blood glutamate has a half-life time of 2-3 min. ► Blood glutamate is submitted to rapid decarboxylation. ► Blood glutamate and its metabolites are mainly absorbed in skeletal muscle and liver. ► The skeletal muscle and liver are now targets for potential drugs affording brain neuroprotection.