کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1931901 | 1050568 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Substoichiometric inhibition of Aβ1-40 aggregation by a tandem Aβ40-1-Gly8-1-40 peptide
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Aβ peptides aggregate to form insoluble and neurotoxic fibrils associated with Alzheimer's disease. Inhibition of the aggregation has been the subject of numerous studies. Here we describe a novel, substoichiometric inhibitor of Aβ1-40 fibrillization as a tandem dimeric construct consisting of Aβ40-1 (reverse sequence) linked to Aβ1-40 via an eight residue glycine linker. At molar ratios of the tandem peptide to Aβ1-40 of 1:10 to 1:25 inhibition of fibrillization, as measured by ThioflavinT, was observed. We postulate that the tandem construct binds to a fibrillar intermediate but the reverse sequence delays or prevents further monomer association.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 397, Issue 3, 2 July 2010, Pages 509-512
Journal: Biochemical and Biophysical Research Communications - Volume 397, Issue 3, 2 July 2010, Pages 509-512
نویسندگان
Sourajit M. Mustafi, Kanchan Garai, Scott L. Crick, Berevan Baban, Carl Frieden,