کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1931903 1050568 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Kaposi’s sarcoma-associated herpesvirus processivity factor-8 dimerizes in cytoplasm before being translocated to nucleus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Kaposi’s sarcoma-associated herpesvirus processivity factor-8 dimerizes in cytoplasm before being translocated to nucleus
چکیده انگلیسی

The processivity factor-8 (PF-8) of Kaposi’s sarcoma-associated herpesvirus (KSHV) plays an essential role in viral lytic replication. PF-8 forms homodimers in solution and is observed as a dimer on the DNA. Here, we show that PF-8 dimerizes in cells and that amino acid residues 1–21 and residues 277–304 of PF-8 (396R) are required for dimerization in vivo. Importantly, we demonstrate that PF-8 dimerizes in the cytoplasm before being translocated to the nucleus. The significance of PF-8 cytoplasmic dimerization as a possible first step in the formation of a prereplication complex is discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 397, Issue 3, 2 July 2010, Pages 520–525
نویسندگان
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