کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1932586 1536788 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lipids modulate H2S/HS− induced NO release from S-nitrosoglutathione
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Lipids modulate H2S/HS− induced NO release from S-nitrosoglutathione
چکیده انگلیسی

Recently we observed that a gas messenger H2S/HS− released NO from S-nitrosoglutathione (Ondrias et al., Pflugers Arch. 457 (2008) 271–279). However, the effect of biological compounds on the release is not known. Measuring the NO oxidation product, which is nitrite, by the Griess reaction, we report that unsaturated fatty acid—linoleic acid and lipids having unsaturated fatty acids: asolectin, dioleoylphosphocholine and dioleoylphosphoserine depressed the H2S/HS− induced NO release from S-nitrosoglutathione. On the other hand, a depression effect of the saturated fatty acid—myristic acid and lipids having saturated fatty acids, dilauroylphosphatidylcholine, dimyristoylphosphatidylcholine, dipalmitoylphosphatidylcholine and distearoylphosphatidylcholine was less pronounced. The inhibition effect increased with the decreasing gel-to-liquid phase transitions temperature of the fatty acids and lipids. We suggest that lipid composition of biological membranes modulates NO release from nitrosoglutathione induced by H2S/HS−, assuming that a reaction of H2S/HS− with unsaturated bonds of fatty acids may be partially responsible for the effect.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 390, Issue 4, 25 December 2009, Pages 1241–1244
نویسندگان
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