کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1932894 1050596 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interaction of Hsp70 with p49/STRAP, a serum response factor binding protein
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Interaction of Hsp70 with p49/STRAP, a serum response factor binding protein
چکیده انگلیسی

Members of the Hsp70 protein family must work with other co-chaperones to exert their function. Herein, we identified a new Hsp70 co-chaperone, p49/STRAP, previously shown to interact with serum response factor. We demonstrated that a fraction of p49/STRAP was cytosolic, and that it interacted with the β-sandwich domain of Hsp70. Although p49/STRAP had little effect on the intrinsic ATPase activity of Hsp70, it reduced the ATP-hydrolytic activity of Hsp70 stimulated by Hsp40, and inhibited the refolding activity of the Hsp70/Hsp40 system. Thus, p49/STRAP can be considered a bona fide co-chaperone of Hsp70.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 389, Issue 4, 27 November 2009, Pages 607–611
نویسندگان
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