کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1933006 1050599 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
LXRβ deficient mice have reduced hepatic insulin clearance during hyperinsulinemic euglucemic clamp
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
LXRβ deficient mice have reduced hepatic insulin clearance during hyperinsulinemic euglucemic clamp
چکیده انگلیسی

The present study addresses the insulin sensitivity in mice deficient in LXRβ (LXRβ−/−) as well as in wild type (wt) mice assessed by hyperinsulinemic euglycemic clamp. Wt and LXRβ−/− mice were fed either a normal chow diet or a high fat and high cholesterol diet (HFCD), and insulin sensitivity was assessed by hyperinsulinemic euglycemic clamps. We show that LXRβ−/− mice have reduced insulin clearance during hyperinsulinemic clamps upon feeding both HFCD and a regular chow diet. Moreover we also observed reduced hepatic inflammation in LXRβ−/− mice compared to wt mice upon feeding an HFCD, despite equal levels of hepatic steatosis. In summary, our results indicate that LXRβ−/− mice have reduced insulin clearance during hyperinsulinemic euglycemic clamps and also reduced hepatic inflammation upon feeding an HFCD for 26 weeks.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 392, Issue 3, 12 February 2010, Pages 436–441
نویسندگان
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