کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1933023 1050600 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Blockade of bradykinin B2 receptor more effectively reduces postischemic blood–brain barrier disruption and cytokines release than B1 receptor inhibition
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Blockade of bradykinin B2 receptor more effectively reduces postischemic blood–brain barrier disruption and cytokines release than B1 receptor inhibition
چکیده انگلیسی

Blood–brain barrier disruption and brain edema are detrimental in ischemic stroke. The kallikrein–kinin system appears to play an important role in the regulation of vascular permeability and is invoked in edema formation. The effects of kinins are mediated by bradykinin receptors B1R and B2R. However, little is known about the exact roles of bradykinin receptors in the early stage of cerebral ischemia. In this study, we demonstrated that ischemia upregulated the level of B1R and B2R at 24 h after reperfusion by immunofluorescence assays, mainly expressed in astrocytes and neurons, respectively, in the ischemic penumbra. Moreover, B2R inhibition more effectively reduced neurological severity scores, blood–brain barrier permeability and cytokines release than B1R inhibition did. Additionally, B2R inhibition also significantly suppressed B1R protein level. Therefore, blockade of B2R may be a more effective strategy for the treatment of ischemic brain injury than B1R inhibition within 24 h after reperfusion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 388, Issue 2, 16 October 2009, Pages 205–211
نویسندگان
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