کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1933030 1050600 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neural stem cells express Oct-3/4
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Neural stem cells express Oct-3/4
چکیده انگلیسی

There remain controversy and disagreement on whether Oct-3/4 is expressed in neural stem cells or not. Although many reports had shown expression of Oct-3/4 in somatic stem and progenitor cells, conditional KO mice of Oct-3/4 in neural stem cells did not show any phenotype. Even pseudogenes are suspected for the “false positive” results. However, we here report that Oct-3/4 but not pseudogenes is actually expressed in neural stem cells. Western blot analysis with multiple Oct-3/4 antibodies also showed protein expression of Oct-3/4. The subnuclear localization of Oct-3/4 is clearly different from that of P19 cells, suggesting that Oct-3/4 might be inactivated by other mechanisms than transcriptional repression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 388, Issue 2, 16 October 2009, Pages 247–251
نویسندگان
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