کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1933064 1050600 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The evolutionary conserved gene C16orf35 encodes a nucleo-cytoplasmic protein that interacts with p73
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The evolutionary conserved gene C16orf35 encodes a nucleo-cytoplasmic protein that interacts with p73
چکیده انگلیسی

C16orf35 is a highly conserved gene positioned upstream of the alpha-globins in humans and other vertebrates. The deduced protein is also highly conserved, it has no defined structural features or domains, and its function is currently unknown. Here we show that the C16orf35 protein has nuclear and cytosolic distribution, and can localize to PML nuclear bodies. The C16orf35 protein was detected in several human transformed cells lines, and studies of transient and stable overexpression indicate that increased levels of C16orf35 inhibit cell proliferation. We also find that C16orf35 interacts with human p73, and represses transcription by TAp73γ but not by TAp73α. This selectivity is not due to differential interaction, since C16orf35 binds both p73 variants. Our data suggest that C16orf35 can modulate differentially the specific activities of selected p73 isoforms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 388, Issue 2, 16 October 2009, Pages 428–433
نویسندگان
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