Elevation of plasma β-amyloid level by glucose loading in Alzheimer mouse models

With the emergence of a promising approach to treat Alzheimer disease (AD) targeting the β-amyloid (Aβ) pathway, it is necessary to establish new diagnostic biomarkers that enable the antemortem diagnosis of AD. Although plasma Aβ has been suggested as a non-invasive biomarker, its significance has been inconclusive. Thus, it is important to improve the diagnostic potential of plasma Aβ. One of the potential approaches is to modify plasma Aβ level using various modulators. In this study, we evaluated the influence of glucometabolic status on plasma Aβ level in two lines of AD transgenic mouse. The present study demonstrated that plasma Aβ level rapidly increased after glucose loading. More importantly, the magnitude of the increase in plasma Aβ was significantly larger in AD transgenic mice than in wild-type littermates. These findings might provide a novel diagnostic tool for AD using the elevation of plasma Aβ level after glucose loading.