کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1934086 1050633 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Staphylococcus aureus surface protein SasG contributes to intercellular autoaggregation of Staphylococcus aureus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Staphylococcus aureus surface protein SasG contributes to intercellular autoaggregation of Staphylococcus aureus
چکیده انگلیسی

Staphylococcus aureus surface protein G (SasG) is one of cell surface proteins with cell-wall sorting motif. The sasG mutant showed significantly reduced cell aggregation and biofilm formation. SasG is comprised of variable A domain and multiple tandem repeats of B domain, native-PAGE and in vitro formaldehyde cross-linking experiments revealed that the recombinant protein of the A domain showed homo-oligomerization as an octamer, but B domain did not. This study shows that SasG-A domain contributes to intercellular autoaggregation by homo-oligomerization, and that may facilitate the adherence to host-tissues in the infection of S. aureus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 377, Issue 4, 26 December 2008, Pages 1102–1106
نویسندگان
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