کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1934381 1050639 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
HOXA10 suppresses p/CAF promoter activity via three consecutive TTAT units in human endometrial stromal cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
HOXA10 suppresses p/CAF promoter activity via three consecutive TTAT units in human endometrial stromal cells
چکیده انگلیسی

Implantation is the first maternal–embryo crosstalk that only occurs during a finite period called the ‘implantation window’. HOXA10, a homeobox transcription factor, plays an important regulatory role during this period. However, the target genes of HOXA10 involved in implantation and decidualization have not been identified. Using a chromatin immunoprecipitation screen, we identified the p300/CBP-associated factor (p/CAF) as a direct HOXA10 target gene in vivo. Adenovirus-mediated overexpression and siRNA-specific knockdown of HOXA10 altered p/CAF promoter activity via interaction with the three consecutive TTAT element units in human endometrial cells. These results indicate that p/CAF is a novel HOXA10 target gene, and HOXA10 promotes human endometrial development, at least in part, through the regulation of p/CAF gene.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 379, Issue 1, 30 January 2009, Pages 16–21
نویسندگان
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