کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1934453 | 1050641 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Induction of allergic contact dermatitis by astigmatid mite-derived monoterpene, α-acaridial Induction of allergic contact dermatitis by astigmatid mite-derived monoterpene, α-acaridial](/preview/png/1934453.png)
α-Acaridial [2(E)-(4-methyl-3-pentenyl)butenedial] is a novel monoterpene secreted from the house dust mites. Because of its molecular nature of a highly reactive, small lipidic compound, we addressed whether α-acaridial might function as a haptenic allergen that induced allergic contact dermatitis. Mice sensitized with α-acaridial were challenged by the same antigen on the ear skin. After 2 days, significant ear swelling with a prominent infiltration of CD4+ T lymphocytes was observed. In vitro, α-acaridial exhibited an outstanding ability to quickly interact with and chemically modify a reference protein. Virtually all cysteine residues and a sizable fraction of lysine residues were found to be selectively modified, suggesting that α-acaridial could potentially interact with any proteins. Previously, numerous mite-derived proteinaceous allergens have been associated with contact dermatitis. Our study now emphasizes that small lipidic compounds released from mites comprise a new class of mite allergens, and therefore, is of significant medical implications.
Journal: Biochemical and Biophysical Research Communications - Volume 375, Issue 3, 24 October 2008, Pages 336–340