کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1934647 | 1050647 | 2008 | 6 صفحه PDF | دانلود رایگان |

LUZP is a leucine zipper-containing protein predominantly expressed in the brain. The functional significance of LUZP remains unknown. To explore the role of LUZP in brain development, a knockout mouse strain with a lacZ knock-in (Luzp-KO/lacZ-KI) has been established. LacZ reporter expression driven by the endogenous Luzp promoter was detected in the neuroepithelium and the cardiac tissue. Luzp−/− mice exhibited perinatal death, presumably due to the accompanied complex cardiovascular defects. Luzp−/− embryos displayed a cranial neural tube closure defect (NTD), with exposed brain tissues. Ectopic expression of Sonic-hedgehog, which is a protein known to be involved in neural tube closure, and elevated apoptosis were observed in the dorsal lateral neuroepithelium of the NTD Luzp−/− hindbrain. These findings assign a novel function of LUZP in the embryonic development of brain.
Journal: Biochemical and Biophysical Research Communications - Volume 376, Issue 3, 21 November 2008, Pages 466–471