کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1934923 | 1050653 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A fatty acid elongase ELO with novel activity from Dictyostelium discoideum
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A fatty acid elongase ELO with novel activity from Dictyostelium discoideum A fatty acid elongase ELO with novel activity from Dictyostelium discoideum](/preview/png/1934923.png)
چکیده انگلیسی
Fatty acid elongation was examined in the cellular slime mold, Dictyostelium discoideum. Profiling of the total fatty acid content of D. discoideum indicated that fatty acid elongation is active. Orthologs of the fatty acid elongase ELO family were identified in the D. discoideum genome and the cDNA for one, eloA, was cloned and functionally characterized by expression in yeast. EloA is a highly active ELO with strict substrate specificity for monounsaturated fatty acids, in particular 16:1Δ9 to produce the unusual 18:1Δ11 fatty acid. This is the first report on fatty acid elongation in a cellular slime mold.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 374, Issue 2, 19 September 2008, Pages 226–230
Journal: Biochemical and Biophysical Research Communications - Volume 374, Issue 2, 19 September 2008, Pages 226–230
نویسندگان
Brenda J. Blacklock, Deborah Kelley, Sonal Patel,