کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1935679 1050672 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Redox modulation of A-type K+ currents in pain-sensing dorsal root ganglion neurons
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Redox modulation of A-type K+ currents in pain-sensing dorsal root ganglion neurons
چکیده انگلیسی

Redox modulation of fast inactivation has been described in certain cloned A-type voltage-gated K+ (Kv) channels in expressing systems, but the effects remain to be demonstrated in native neurons. In this study, we examined the effects of cysteine-specific redox agents on the A-type K+ currents in acutely dissociated small diameter dorsal root ganglion (DRG) neurons from rats. The fast inactivation of most A-type currents was markedly removed or slowed by the oxidizing agents 2,2′-dithio-bis(5-nitropyridine) (DTBNP) and chloramine-T. Dithiothreitol, a reducing agent for the disulfide bond, restored the inactivation. These results demonstrated that native A-type K+ channels, probably Kv1.4, could switch the roles between inactivating and non-inactivating K+ channels via redox regulation in pain-sensing DRG neurons. The A-type channels may play a role in adjusting pain sensitivity in response to peripheral redox conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 370, Issue 3, 6 June 2008, Pages 445–449
نویسندگان
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